new thiamine book

Thiamine Deficiency Gaining Recognition: New Book

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In the 5 years since Dr. Lonsdale and I published our book: Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition (and 50 years since Dr. Lonsdale first began working with thiamine) recognition of the role of thiamine in health and disease have increased steadily year over year. Sales of the book double each year. Admittedly, the numbers were low and remain low in comparison to other popular topics, but the increase in awareness is heartening. Unfortunately, much of this awareness has not reached the medical profession. We regularly see reports in the medical literature boasting recognition of ‘rare’ cases of thiamine deficiency diseases like beriberi and Wernicke’s. If only physicians knew how common these conditions were and that they are only rare because we are not looking. Insufficient thiamine is Hiding in Plain Sight.

A New Book

In 2020, a UK physician by the name of Jo Dixon published a new book on thiamine deficiency, a personal account of her declining health, her discovery of thiamine, and her efforts to get treatment and spread the word. The book, called The Missing Link in Dementia, A Memoir, documents her journey. Unfortunately, she neither mentions thiamine in the title, the description, or even in the text until halfway through. One would not know the book is about thiamine until one reads it or unless it is recommended, so I will recommend it here. This would be a great starter book for someone beginning their health journey.

She has a second book listed on Amazon, Swimming in Circles that I have not read, but I suspect it details thiamine deficiency in fish in other animal populations.

While I would have preferred her to mention thiamine deficiency in the title or introduction, I found the book quite telling of the lengths one has to go to uncover this deficiency, even as a physician. Her case, unfortunately, is highly typical of what we see in patients everywhere. She had longstanding bowel dysfunction, which limited her ability to eat and maintain nutritional status. She led a busy life as a physician and mother of four children, which put pressure on thiamine stability. Even so, she functioned quite well for a long time. It wasn’t until her health took a severe turn for the worse that thiamine deficiency was recognized. Like others who develop issues with thiamine, she was forced to diagnose herself. No other physician, and she saw many, could provide any answers to her declining health. She had to figure it out herself. She was also forced to treat herself. Fortunately for her, she convinced a physician friend to provide IV thiamine, a protocol that was not accepted by her hospital and one she could not readily provide to other patients when she identified their deficiencies.

All of this is typical. We believe that thiamine deficiency was solved and thus any cases that do appear must be rare (to a tee, most case reports include ‘rare’ in the title or introduction). In reality, they are only rare because we do not look for them. We believe falsely that thiamine deficiency emerges acutely, and while it does in some cases, mostly it sits in the background, quietly and insidiously destroying one’s health. We have cases of high functioning individuals whose health begins to decline and whose thiamine levels are tested as low and should merit treatment but ignored for years as not being pertinent. And those are the lucky ones. Most physicians refuse to test for thiamine.

Thiamine deficiency is easily treatable if recognized early. It becomes more complicated as the years pass, and it is impossible if we never bother to look.

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Photo by Alif Caesar Rizqi Pratama on Unsplash.

Chandler Marrs MS, MA, PhD spent the last dozen years in women’s health research with a focus on steroid neuroendocrinology and mental health. She has published and presented several articles on her findings. As a graduate student, she founded and directed the UNLV Maternal Health Lab, mentoring dozens of students while directing clinical and Internet-based research. Post graduate, she continued at UNLV as an adjunct faculty member, teaching advanced undergraduate psychopharmacology and health psychology (stress endocrinology). Dr. Marrs received her BA in philosophy from the University of Redlands; MS in Clinical Psychology from California Lutheran University; and, MA and PhD in Experimental Psychology/ Neuroendocrinology from the University of Nevada, Las Vegas.


  1. I have POTS. IBS-D, migraines, neck pain and muscle pain. I have just started allthiamine very low dose at 25mg – will this cause more IBS-D

  2. Dr Marrs, I’m so intrigued by your Thiamine deficiency book and it’s link to Dysautonomia. We are desperate to get my 20 yr old daughter help. We’ve seen 11 specialists with no help, no answers. They don’t know what to do. She’s been diagnosed with POTS, then secondary adrenal dysfunction, hypoglycemic, and aqua genic urticaria, fatigue….She can’t gain weight struggles every day. Can u check thiamine with bloodwork? How much should she take to see if this is our missing piece to her puzzle. I’m trying to get my hands on this book. Thank you, Amy Young

  3. Thank you, doctor, for sharing your knowledge, very important information with people. It’s a pity that I didn’t know this 10 years ago …. but the doctors probably knew the importance of B1 … It’s clear that they knew if they prescribed cocarboxylase, and this was not enough, you had to drink the vitamin itself with its derivative

  4. Humans have introduced dangerous artificial stressors above those that occur naturally in our world. We are faced with adapting, or succumbing, to them. I have repeatedly written about the lifework of Hans Selye on Hormones Matter. He studied the effects of stress in animal systems. He concluded that each form required a bolus of energy to run the complex defense machinery. He called this the General Adaptation Syndrome (GAS). Failure to produce the extra energy spelled disease. He called this a failure to adapt (to the stress) and human diseases were called “diseases of adaptation”. Skelton, one of Selye’s students, was able to initiate the GAS in an animal by making it thiamine deficient, emphasizing the role of energy. Perhaps TTFD, by its ability to stimulate energy production, could be a universal treatment for all disease. It is suggested that the variability of symptoms represents the degree of energy lack and its distribution in the body;

    • Hello Derrick! Glad to see you are still alive and active. I continue to work on bringing the latest anti-aging remedies to the public but you seem
      To have already found some answers and are using them
      Successfully. My latest rendition is an extension of the plasma dilution of 5% albumin mixed 1:1 with saline to replace the older persons plasma
      method by co- culturing their bone marrow stem cells with umbilical cord stem cells. This is said to convert the old stem cells back
      Into youthful stem cells. We have four cases now we are working with so hope to see good results soon. Best Regards, David

  5. Dr. Marrs,

    In someone who is apparently healthy, with no signs or symptoms of thiamine deficiency, what form of thiamine, and what dosage would you suggest in order to prevent a deficiency in the future, also, assuming the individual’s diet is not ideal?

    • If you are not having any symptoms, depending upon your diet, medication, and alcohol usage, anywhere from 25-100mg of thiamine HCL should be fine. Remember though, because thiamine affects energy metabolism in the mitochondria, and the mitochondria affect everything, symptoms can be broad and seemingly random long before the recognized symptoms of thiamine deficiency appear.

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