thiamine deficiency Archives - Page 12 of 14

A Scientific Sermon on the Basis of Disease

Published on March 15, 2018

7.8K views

Why a sermon? The title was suggested from a breakfast discussion that I had with a resident in the retirement home in which I live, a retired minister of the United Christian Church. In the nearly 5 years that I have been living here, I have repeatedly sat and listened to my friends talking about their various handicaps and how they are being treated. I was a pediatrician at the Cleveland Clinic for 20 years and left it in 1982 to practice what has become known as “Alternative Complementary Medicine”. Because few people apparently understand the meaning of this, I am trying here to inject a little bit of science to explain it.

From the Unexplainable Comes Insight

In 1982, I began to see adults as well as children. I thought that there might be some interest in why my perspective changed and why I took early retirement from a prestigious orthodox medical institution. As a consultant pediatrician at the Clinic, I was exposed to the referral of children with strange diseases. There is a group of genetically determined rare conditions known as inborn errors of metabolism. The strange thing about them in common is that if they are not recognized at birth, some of these diseases cause the affected child to become mentally retarded. That is why there is a laboratory in each state capital that tests every newborn child for one of these inborn errors. It demands only a finger stick of blood on a strip of filter paper that can be mailed to the laboratory. Perhaps even stranger, many of them can be protected from mental retardation by starting them on a special diet that they have to maintain throughout life. It forced me to understand the necessary biochemistry, the nature of the special diet and why it prevented mental retardation.

One day, because of my studies in biochemistry, I was confronted with a 6-year old child with a weird story. I will refer to him as JV. He had suffered from infancy with intermittent episodes of a condition known as cerebellar ataxia (ataxia is a fancy word used to describe a lack of balance and coordinated movement). The cerebellum is part of the brain that deals with balance amongst many other responsibilities. Each one of these episodes lasted about 10 days, rose to a clinical climax and subsided automatically without treatment, just as though he had been drinking alcohol. Each episode left him a little bit more mentally affected. His clinical presentation was exactly like that of a drunk. He was unable to walk a straight line and his speech remained slurred as long as the attack lasted.

Alcohol has its major effect by inducing vitamin B1 deficiency in the cells that make up the cerebellum. He had been tested with every known method by neurologists and neurosurgeons, all of which produced no information.

To cut a long story short, I had to wait two years before he had one of these episodes when I admitted him to hospital for study. All I did was to collect urine that was subjected to biochemical testing. His urine was collected continuously for 12 hours during the night and separately for 12 hours during the day to see if it reflected differences in night/day metabolic processes. The ataxic episode lasted about 11 days, rose to a symptomatic climax at about the sixth day and gradually subsided without any treatment whatsoever. Of some interest, during the last few days the symptoms would be much less in the morning and gradually worsen as the day advanced. The abnormal chemical changes were reflected in the urine by being alternately high during the day and much lower during the night. Thus, the day/night rhythm of the brain known as circadian (circadian means about 24 hours) was affected. Yes, our brains are constructed to dovetail with the day/night seasonal rhythms of our world.

Without going into complex details I was able to show that he had vitamin B1 dependency. The chemical name for this vitamin is thiamine. Vitamin dependency means that a much greater amount of the vitamin is necessary for its normal action. Vitamins act as what are called cofactors to enzymes. The connection between the vitamin and its respective enzyme is under genetic control and it was this mechanism that was defective.

High Dose Nutrient Therapies to Compensate for Energetic Demands

From this case, I learned that this genetic defect might be overcome by using pharmacological doses of thiamine. It seemed as though the vitamin acted as a drug by stimulating the inefficient enzyme back to a more normal state of function. In a fanciful analogy, some man-made machines require cogwheels that transmit energy from the power source to the action. Enzymes in the body may be roughly compared with cogwheels. They transmit energy derived power to physical and mental action. To continue the analogy, cogwheels require oil and vitamins may be roughly (and I mean roughly) compared to oil given to a cogwheel. They are each essential components that engage with their respective enzymes. Without the appropriate vitamin, the corresponding enzyme gradually becomes dysfunctional.

As I have already noted, the connection between a vitamin and its respective enzyme is controlled by a genetically dependent mechanism. It is the breakdown of this mechanism that introduces dependency. Each of this child’s episodes of ataxia was triggered by a simple infection like a cold, a mild head injury or even an inoculation. I will refer to this as some form of stress. Several reports in the medical literature describe intermittent clinical episodes of their respective disease entity being exacerbated by an otherwise mild infection. This is important because sometimes a mild head injury or an infection is thought to be the cause of the generated symptoms on its own, whereas it may well be triggering the clinical situation in relationship to hitherto marginal energy availability.

The point that I am trying to make is that the injury, and indeed the defense against infection, automatically demands an energy-dependent response. That marginal energy availability may not be enough before the injury to cause symptoms, or perhaps mild symptoms in such an individual might be ascribed to other causes as conceived within our present medical model. For example, a given symptom may be “written off” as an allergy, thus confounding the situation even more. Energy is always required by the brain in order to respond to any form of mental or physical stress. Just as a car consumes more energy when climbing a hill, stress to us is like a hill to be climbed. This action takes place automatically when our capacity to synthesize energy is healthy.

If the increase in energy is not forthcoming, the affected cells do not function properly, giving rise to what we call symptoms. Symptoms are inevitably generated by sensory mechanisms in the brain, another factor which can be very confusing. For example, an injury in an elbow would result in a signal to the brain that generates the sensation called pain. The brain acknowledges the signal by announcing to its owner “I have a pain in my elbow”. The point is this; pain is a brain effect and can explain why there is such a phenomenon as psychological pain.

The Irony of Psychosomatization

I want to impress you however that psychology is always due to electro-chemical brain cell reactions because it has a scientifically plausible explanation. That means that so-called psychosomatic disease is not an invention by the patient. The symptoms are being generated by chemical disturbance in those brain cells and in today’s world, high calorie malnutrition is responsible for polysymptomatic diseases that haunt many physicians’ offices. They are often referred to as “problem patients” and the patient is sometimes told that it is “all in your head”. The irony is that this is the truth. It certainly is in the head but it has a real underlying cause that is being misinterpreted.

I recently read a column in the Wall Street Journal entitled “Is your teen depressed”? With direct quotes from this column “statistics show that teen depression is on the rise. In 2016 around 13% of US teenagers aged 12 to 17 had at least one major depression episode in the past year compared to almost 8% in 2006. The American Academy of pediatrics has recently recommended screening all those youngsters aged 12 and older annually for depression. They define major depressive disorder as having five or more of the following symptoms present for two weeks: depressed mood most of the day, irritability, decreased interest or pleasure in most activities, significant change in weight or appetite, change in sleep, increased educational sluggishness, fatigue or loss of energy, feelings of guilt or worthlessness, changes in concentration and recurrent thoughts of death. They sometimes complain of stomachaches or headaches that don’t have an identifiable cause”. My explanation is the combination of three factors, represented as three interlocking circles of health, genetic risk/stress/nutrition.

Genes, Nutrition, and Energy

Let me explain genetic risk a little. We now know that our genes can be manipulated by nutritional elements and lifestyle. Many genetic diseases do not appear until late in life. If it was only the gene to blame, one would expect it to appear at birth and indeed some do. For example, type I diabetes has genetic determination but the symptoms may not appear until middle age and are often associated with some form of stress such as a cold, a mild injury or even a telegram giving bad news. Some recent research has shown that pharmacologic doses of thiamine might well protect diabetics from their well-known complications.

Thiamine is a vital naturally occurring chemical (the word vitamin was used to express its vital need for life when it was thought to be an amine. When it was synthesized and found not to be an amine the terminal e was dropped) that enables body cells to produce the energy they require for function and we have between 70 and 100 trillion cells that make up the human body, all of which require energy. Vitamins act as what are called cofactors to enzymes. JV actually had intermittent episodes of a classical disease known as beriberi, long known to be caused by deficiency of thiamine. However, because of genetic mechanisms that were at fault, he required huge doses of thiamine in order to prevent his intermittent episodes of beriberi, hence the use of the term dependency.

The RDA (recommended daily allowance) for thiamine is 1 to 2 mg a day and he required 600 mg a day. If he should succumb to a cold, experience a simple injury or some other form of physical stress, he found that he had to double the dose to 1200 mg a day. Contrast this with 1 to 2 mg a day as the RDA indicated for normal healthy people. On one occasion an episode occurred following an inoculation, so I had to assume that the inoculation represented some form of physical stress. Note that the needle stick sends a sensory message to the brain, notifying it of some form of attack. The signal causes the brain to formulate any necessary defensive action. Therefore, if somebody passes out following a needle stick, it is a temporary lack of energy mobilization in the brain.

I must emphasize again: the brain requires energy mobilization to meet any form of stress. Therefore, our energy consumption is in a constant state of flux on a day-to-day basis, much like climbing hills and descending into valleys on a journey For example, when this child was under treatment he was walking in a local park, tripped on a stone and suffered a relatively mild head injury. He became unconscious and was taken to a nearby emergency room. His mother called to notify me of the event. I called the physician in the emergency room and tried to explain to him that this child represented a special case and that he required an injection of thiamine. He thought that I was quite mad: such is the trust that leads to failure of communication between physicians.

Thiamine and Energy

This was such an intriguing experience that I began to perform clinical and library research on vitamins that have continued to the present. Glucose is the “gasoline” that is the major fuel of our cells and thiamine is the equivalent of the “spark plug”. The energy requirement for the brain and heart is enormous because both of them function 24 hours a day throughout life. That is why energy deficiency disease dominates the brain and heart with varying degrees of severity. Because I was a consultant pediatrician, I received referrals from private pediatricians in Ohio and even out-of-state. Some of my common referrals were children with attention deficit, hyperactivity, learning disability and other curious distortions of behavior. Of course I discovered that their diet was atrocious and using pharmacologic doses of thiamine brought them back to normal behavior. Not only that, I found that some of the strange diseases referred to the Clinic also responded to vitamin therapy, so I offer this explanation.

Every cell in the human body is a one-celled organism in its own right. Evolution has endowed each of them with special responsibilities in groups that make up the organs of the body. I think of the body as being somewhat like an orchestra where the groups of specialized cells represent the instrumentalists. The violins, as it were, are separated from the cellos, each representing a bank of instrumentalists. They all know what to do but require a conductor. The conductor in the body is of course that part of the brain that connects with all the organs through the nervous system known as autonomic. We have two types of nervous mechanisms: the voluntary system conveys will, thus allowing conscious control of body movement and thoughts. The autonomic nervous system is purely automatic. Its controls are in the lower part of the brain which is unusually sensitive to deficiency of thiamine. That is why alcohol addiction, heavily related to thiamine metabolism, results in a brain disease known as Wernicke encephalopathy that is well known to be caused by thiamine deficiency.

Signals from the brain to the body organs and from the organs to the brain enable us to adapt to all the vagaries of living in a hostile environment. This signaling system also requires a huge amount of energy and it is not surprising that the brain/body mechanisms deteriorate if there is insufficient energy.

I have come to the conclusion that thiamine is somewhat like the leader in an orchestra. Although the entire vitamin category represents the nutrient necessities of life and each has its own separate responsibility, they all work together. Because of its special place in energy metabolism it stands out with its clinical importance. Because energy metabolism is frequently inferior as the major cause of a disease, the diagnostic category, as we presently represent disease, ceases to matter. A reader might object by referring to genetically determined disease as a leading cause. However, the new science of epigenetics tells us that proper use of nutrients and adjustments of lifestyle can often correct the genetic mistake.

High Calorie Malnutrition: A Disease of Affluence

Now I would like to discuss what I mean by high calorie malnutrition because I believe it is an extraordinarily common cause of disease in our disorganized world. Malnutrition is usually thought of in relationship to starvation. The disease known as beriberi is a classic example of high calorie malnutrition. It was caused for centuries by the consumption of rice. Although the major effect has been in Eastern countries, it has appeared in many different parts of the world including America. The rice grain consists almost exclusively of starch that is broken down to glucose for use as fuel. The vitamins necessary for the metabolism of the glucose are in the cusp around the grain. When you remove the cusp you generate white rice and the Chinese peasants found that white rice looked nicer on the table. Therefore if and when they became more affluent they would take their rice to the rice mill for the removal of the cusps. The use of the rice mill was expensive, hence the association with affluence. They would place the white rice in silver bowls and invite their friends to dinner, not for culinary purposes but to demonstrate their new found affluence. Our constant deviation from the natural rules applied to health costs humanity dear. People with beriberi do not look starved. In fact they may be obese. Because they have bitter complaints and look relatively healthy they are often mistaken for neurotic complainers and treated indifferently. Not only that, if a physician might suspect his patient as having this disease and measure the level of thiamine in the blood he will probably find it to be normal. It is the ratio of calorie concentration to that of thiamine concentration, reminding me of what happens with too much gasoline in the cylinder of a car referred to as a choked engine.

I would like to give you a few examples. When I started my library research on thiamine, I discovered that a medical officer of health in England had been sent out to Hong Kong in the 1940s to investigate a form of sudden death that occurred in breast-fed infants of Chinese mothers. Hong Kong was then a British protectorate. She found that the rice consuming mothers gave their infants thiamine deficient breast milk. Although these infants were often considered to be the healthiest looking members of the family they suddenly died at the age of 3 to 4 months, exactly like sudden infant death syndrome that occurs today. Of historical interest, you may remember that the Japanese invaded Hong Kong and the Chinese people had their rice severely restricted. Although the breast feeding mothers were near to starving, the sudden infant death ceased to occur. When the Japanese were driven from the colony, the mothers had unrestricted rice and the sudden infant death began to reappear. This taught me the danger of empty calories.

At the Clinic, I kept seeing infants that had been classified as “threatened sudden infant death” and would place them on a breathing monitor that indicated when they had an episode of apnea (temporary cessation of automatic breathing) or slowing of the heart. When I gave them thiamine the monitors ceased to fire alarms. By special studies we found that the function of the brain stem in these infants was compromised, clearly indicating an electrochemical underlying mechanism. Although we published our work, it has been ignored. Advancing to my experience with adults after I had resigned from the Clinic a young woman came to see me from out-of-state. She had been diagnosed with a condition known as thrombocytopenic purpura, a disease in which platelets, one of the varieties of cells in the blood that have a function in clotting, were severely deficient. She had been receiving orthodox treatment for 10 years without success. I gave her a series of intravenously administered water soluble vitamins with complete resolution. I can provide lots more examples, but perhaps this has introduced to you the possibility of a different perspective in our constant search for what health really means and how it breaks down into disease. The bottom line, if you will, may come down to simple energy availability. If that is the case, then all disease processes, no matter their origins, would benefit from improving energy capacity.

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Two New Cases of Beriberi-like Syndromes: Thiamine Deficiency in Modern Medicine

by Derrick Lonsdale MD, FACN, CNS

Published on January 9, 2018

15.6K views

As a result of my participation in Hormones Matter, I receive quite a few emails that record histories of patients who have often languished with inexplicable symptoms, sometimes for years. I am going to record two histories here without identifying any possibility of the involved patients being recognized.

Patient number 1: Cyclic Vomiting, Hyper-salivation, Sensory and Neurological Issues

This is the story of a boy who had what was described as “chronic cyclic vomiting from 11 months until 24 months of age, sometimes 3 to 4 times a day”. Food refusal with chronic vomiting and severe weight loss (failure to gain) was described. His diet was recorded as consisting basically of chicken/beef and vegetables. Frequent use of Paracetamol for ear infections with fever was described. As an infant he experienced hyper-salivation, bad enough for wearing a bib 24/7. Extreme sensory issues were mentioned but were not specified. Dilated pupils from a very young age***, neurological issues with confusion, memory problems, speech difficulty and heart racing/palpitations were mentioned together with eye tracking difficulties. A high concentration of arsenic had been found, presumably in urine, although this was not specified. Candida, a form of yeast, had evidently been a frequent infection. He was reported to have Hashimoto (a thyroid dysfunction) and a high blood glucose ***. He exhibited complete lack of coordination, always “appearing drunk”, talking gibberish and repetitive behavior.

Discussion of Symptoms: Patient 1

Cyclic Vomiting

Sometimes known as winter vomiting, the cause of this relatively common condition is said to be unknown. Recurrent vomiting is one of the symptoms recognized for centuries in the thiamine ( vitamin B1) deficiency disease, beriberi. I had several patients with cyclic vomiting, described in our book (Thiamine Deficiency Disease, Dysautonomia and High Calorie Malnutrition) that responded to thiamine treatment.

Food Refusal

Appetite is governed in the lower brain by several hormones, explaining why a voracious appetite and food refusal could both be a signature of thiamine deficiency, depending on severity and chronicity of the deficiency.

Weight Loss

Severe weight and stature increase (failure to thrive), is a signature finding in familial dysautonomia, a genetically determined disease. Thiamine deficiency also causes dysautonomia. I reported a patient with eosinophilic esophagitis whose dysautonomia resulted in failure to thrive. With thiamine treatment his weight and height increased dramatically (see: Eosinophilic Esophagitis May Be a Sugar Sensitive Disease).

Ear Infections

Extremely common in children, this and jaundice of the newborn are both now known to be the result of inefficient oxygen utilization. Thiamine deficiency is an outstanding cause.

Excessive Salivation

The salivary glands are under the control of the lower brain and this fits with thiamine deficiency.

Extreme Sensory Issues

This is the result of inefficient oxidative metabolism in brain and has been a well known problem in thiamine deficiency beriberi. It is interesting that diabetics are sometimes pulled over and accused of drinking because of erratic driving and subsequent “drunken” behavior. I strongly suspect that this is a thiamine deficiency affect, because thiamine metabolism has recently been found to be closely related to metabolism in diabetes.

Permanently Dilated Pupils ***

This is a cardinal sign of sympathetic nervous system overdrive, fitting in with the diagnosis of dysautonomia.

Neurological Issues: Confusion, Memory, Speech, and Eye Tracking Problems

All of this is the result of inefficient oxidative metabolism in brain.

Tachycardia

This is the term for a fast heart rhythm and is a cardinal sign of dysautonomic sympathetic nervous system overdrive.

Urinary Arsenic

Pressure-treated wood in the United States contains a significant amount of arsenic and is generally touted as being the source for children using playgrounds. This is much more significant than arsenic in drinking water. Arsenic damages oxidative metabolism and could be contributive to the effects of thiamine deficiency.

Candida Infections

Candida is a common form of yeast that infects humans. It dislikes oxygen: consequently this infection is much more likely to occur in people whose oxygen metabolism is inefficient.

High Blood Glucose***

Of course, this means that the patient has some form of diabetes. Both type I and type II diabetes are now known to have thiamine deficiency as part of the syndrome. Alzheimer’s disease may be diabetes type III. Thiamine is absolutely vital in glucose metabolism.

Pattern Suggests Pyruvate Dehydrogenase Complex Disease

Pyruvate dehydrogenase is an enzyme that demands thiamine and magnesium in order to function properly. I would be willing to bet that this boy would be responsive to high doses of Lipothiamine and should be studied in detail by a physician who understands the possibility of inborn errors of metabolism. Note the two starred items above. The observation of permanently dilated pupils indicates excessive activity of the sympathetic branch of the autonomic nervous system. The high blood glucose is a sure indicator that thiamine metabolism is involved, even if there is insulin deficiency.

Patient number 2: ROHHAD

This is a little girl, age not specified. She was described as a patient with ROHHAD. This stands for “rapid onset weight gain, hypothalamic dysfunction and autonomic dysregulation”. The parent described this as “a very rare syndrome and only 150 cases have been recorded worldwide”. Children with this diagnosis are said to have similar symptoms. Most of them have central and obstructive sleep apnea. Many depend on CPAP. This child requires it only during sleeping but many other kids have tracheostomy and all are living on CPAP day and night.

Symptoms of patient 2: Sweaty Palms, Cold Intolerance, Tachycardia and More

At my request, the parent observed that there was no family history of alcoholism or smoking. The mother had been thinking of thiamine deficiency because of the child’s autonomic dysfunction. I have noticed that alcoholism and sugar sensitivity appear to be closely related genetically.

She has palm sweating. Father has blepharospasm (spasm of the eyelids) frequently, lasting for weeks at a time. She also has tachycardia (fast heart rate), excessive vomiting, cold intolerance with persistent cold extremities, peripheral neuropathy, binocular diplopia, double vision, gastrointestinal dysmotility, mood swings, and low pain perception are all symptoms of dysautonomia, the commonest cause being thiamine deficiency. Fortunately the family is working with a physician who had started thiamine treatment for this child. The parent closed with the remarks that “since she started TTFD she is having a fast heart rate at 140 beats a minute and low oxygen saturation with restless sleep. I decreased TTFD from 250 mg to 50 mg but my opinion is that she became more stable with oxygen saturation and pulse rate”.

Discussion of Symptoms: Patient 2

ROHHAD

Rapid weight gain, hypothalamic dysfunction, dysautonomia and sleep apnea are all included in this syndrome. I must point out that the word “syndrome” is always used for a collection of symptoms whose cause is unknown. In fact, all can be caused by thiamine deficiency.

Palm Sweating

Sweating is a result of sympathetic nervous system overdrive. She also has tachycardia, excessive vomiting, cold intolerance, peripheral neuropathy and double vision. Various forms of peripheral neuropathy are cardinal symptom in thiamine deficiency.

Gastrointestinal Dysmotility

The intestine is innervated by the vagus nerve which originates in the brain. This nerve uses a neurotransmitter known as acetylcholine, highly dependent on energy metabolism and therefore also dependent on thiamine. Japanese physicians have used thiamine derivatives for years to treat postoperative intestinal paralysis.

Mood Swings

I learned the hard way about mood swings in children when I found that the dominant cause was poor diet resulting in thiamine deficiency.

Low Pain Perception

Decreases in pain perception are described in familial dysautonomia, a genetically determined condition. Thiamine deficiency results in dysautonomia and may well be responsible for low pain perception.

Points of Consideration: Polysymptomatic Disease and Thiamine Deficiency

Both these children have fallen into diagnostic cracks. It seems only to be the persistence of struggling parents that do their own research and persist in trying to find an adequate explanation that addresses the plight of these children. To me, the problem is obvious. Polysymptomatic disease that affects so many body systems can only be explained by some form of energy deficiency, dependent on oxidative metabolism. Thiamine deficiency, arising from both genetic and nutritional abnormalities is a common cause. It could be a simple thiamine deficiency from diet but this is unlikely in the case of these two children who may have a genetically determined condition that is responsive to megadose thiamine.

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A New Model for Medicine

by Derrick Lonsdale MD, FACN, CNS

Published on October 23, 2017

6.2K views

What is a Medical Model?

In the Oxford English dictionary the word model is defined as “design to be followed, style of structure”. Then it follows that there must be a model to distinguish health from disease, that differentiates the two states of being. No disease can be treated without knowing exactly what caused it. Let us go back to Hippocrates, 400 BCE, who said “let food be your medicine and your medicine be your food”. What Hippocrates was saying was essentially that nutrition was the core issue in the maintenance of health. At this time and throughout the Middle Ages there was no model for the cause of disease. Consequently, treatment was extremely primitive and almost purely empirical. In the time of ancient Egypt it was believed that mental illness was caused by the presence of evil spirits in a person’s head. They bored holes in the skull to let the evil spirits out. If you think about that, perhaps it relieved the occasional headache because of increased pressure in the skull caused by a brain tumor. Hence, a few successes might have caused it to be retained as beneficial. During the Middle Ages, the only treatment that seems to have been used is bloodletting. It might have been temporarily useful in people with high blood pressure. A few successes yielded the conclusion that it was beneficial for all disease.

The First Controlled Experiment

Semmelweis was a 19 ^th century Hungarian physician. In those days, the incidence of puerperal disease (childbed fever) was absurdly high. Semmelweis made the observation that doctors, delivering their patients, entered the delivery room and went directly to their patients without changing their garments or washing. He came to the simple conclusion that the doctors were bringing something in with their hands that caused the problem. The obstetric ward consisted of a number of beds on each side of the room and Semmelweis directed that doctors delivering their patients on one side should wash their hands in chlorinated lime, while doctors on the other side of the room would continue in the old way. Of course, the incidence of childbed fever was so different that it did not need a statistician to document the difference. Semmelweis’s observations conflicted with the established scientific and medical opinions of the time, particularly as he was unable to explain what was on the hands of the doctors. Some doctors were even offended at the suggestion that they should wash their hands. It is truly an amazing vision of human behavior. Innovation carries with it loss of reputation for the innovator, no matter how successful the innovation. Well, of course everyone today knows that it was microorganisms on the hands of the doctors that caused the disease, but they had not yet been discovered. Poor Semmelweis wound up in a lunatic asylum and died in his 40s after a beating by attendants. Today, he is regarded as the first person to introduce antiseptic medicine.

The First Paradigm in Medicine: Microscopic Organisms

Most people are aware that the invention of the microscope, and the work of historical figures like Louis Pasteur, led to the discovery of organisms, that could only be seen with the microscope, caused what we now call infection. We are all familiar with the fact that a tremendous number of diseases are due to infection by bacteria, viruses or fungi. It was a perfectly logical conclusion that the development of treatment should be aimed at killing these organisms. This was the first paradigm in medicine, meaning that it was accepted by all. A glance at history will tell us that the search for medication that would kill these organisms was hard won. It was difficult to find something that would kill the germs without killing the patient and many patients lost their lives as a result of this search. The discovery of penicillin represented a dramatic change in perspective as it gave birth to the antibiotic age. Millions of lives have been saved. However, we are now entering an era where the development of antibiotic resistance is becoming an increasing problem. More and more potentially damaging antibiotics have been synthesized that present their own problems in therapy.

The Second Paradigm in Medicine: Immunity

It has been said that Louis Pasteur made the statement on his deathbed, “I was wrong: it is the defenses of the body that matter”. I believe that this may well become the second paradigm in medicine. So what are we talking about? Everyone recognizes that we have immunity but the average person has only the vaguest idea of what this really means. In fact, body defenses against infection are exquisitely complex and incredibly efficient when the immune system is healthy. The primary mechanism for health maintenance is exactly what Hippocrates said, not only the quantity but the quality of nutrition. By recognizing this, the concept is offered that preventive medicine, the use of nutrients based on a knowledge of the biochemical machinery that give our cells function, is the second paradigm.

Presently, we stimulate our immunity by the use of vaccines. However, each vaccine gives a protection to a specific microorganism, perhaps the best example being the flu. Most of us are aware that there are many strains of the flu virus and it may not be possible to predict the particular strain responsible for the “next epidemic”. Natural immune defense mechanisms recognize most invaders as “enemies”. Those whose adaptive/immune mechanisms cannot respond will succumb to the infection. Assisting the immunity mechanisms by making energy synthesis as efficient as possible and killing the “enemy” with maximum safety to the patient might just be the way of the future.

How the Body Responds to Environmental Stressors

Each one of us comes with a “blueprint” derived from our parents in the form of genes that carry a code called DNA. This code is unique for each person and provides the structure that makes up a living person. The body is composed of 70 to 100 trillion cells, all of which have to cooperate to produce what we call function. I think of it being like an orchestra where all the organs are made up of cells, each one of which has a specific specialty to provide its contribution. Like instrumentalists in an orchestra, the cells within each body organ have to work together. This requires a conductor, a function that is performed by the subconscious brain. Coordination is administered through an automatic (autonomic) nervous system and a bunch of glands known as the endocrine system that produce messengers called hormones.

Consider what happens when a person is attacked by a pathogenic Streptococcus, for example. The throat becomes sore, the marker of inflammation. Controlled and executed through the brain, it increases local blood supply, bringing white blood cells into the area and is part of a defensive process. Glands in the neck become enlarged and this is also a defensive process, designed to catch and destroy the germs beginning to spread. Body temperature becomes elevated because disease producing bacteria are most virulent at normal body temperature and their efficiency is reduced at a higher body temperature. A standard procedure in medicine for many years has been to reduce the fever and it has always seemed to me to be a disadvantage, based on this explanation. We sweat when the environmental temperature is high and evaporation from the skin results in cooling. When the environmental temperature is low, we shiver and the muscular activity produces heat to maintain body temperature. These are examples of how we are able to adapt to changes in our environment that threaten our well-being. All of this is purely automatic and the only thing to complete the picture is how our food (fuel) is used to create energy. Maximum efficiency of brain metabolism is mandatory. Assist and protect the “conductor”.

How We Create Energy: Enter the Mitochondria

Because any form of burning is the union of oxygen with the fuel, in the body it is termed oxidation. The process is complex and many vitamins and minerals are involved, besides calories. It has long been known that thiamine (vitamin B1) deficiency is the cause of beriberi, the disease that had plagued humanity for thousands of years. Because this deficiency affects every cell in the body, it can degrade the efficiency of virtually any organ. But because different tissues have their own rate of metabolism and the brain and heart are the two tissues that require fast and efficient oxidation, it is the cells in those tissues that are most affected. Therefore, thiamine deficiency has its major effect in the brain and heart, but they are not exclusive.

Glucose is the main fuel, but like any other fuel used to produce energy, it has to be ignited. Thiamine, much like a spark plug in a car, processes this ignition. All simple sugars taken in the diet are broken down to glucose. But before this happens in the body, dietary sugars have two effects. The first is a signal from the tongue to the pleasure zones of the brain. It is this sweet taste that makes sugar addictive. The second is that this excess of sugar overwhelms the capacity of thiamine to oxidize glucose to create energy. A person may have a perfectly normal thiamine level in the blood that is inadequate to meet the demand. It is the ratio of “empty carbohydrate calories” to the concentration of available thiamine that counts. I have called this “high calorie malnutrition” that seems to be an oxymoron since malnutrition is generally considered to be on the way to starvation. The patients with this form of malnutrition may be obese, remain relatively active, do not look ill and multiple symptoms are regarded by their physicians as “psychologic, or psychosomatic”. There appears to be no reason to seek laboratory evidence of malnutrition and the patient is written off as a “problem patient”. It is hardly surprising that the patient leaves the doctor’s office angry and tells friends that “the doctor told me that it was all in my head”.

The irony is that it IS in the patient’s head, but because of electro-chemical changes in brain metabolism. It has always seemed odd to me that physicians often consider that “psychological issues” are somehow “invented” by patients without thinking that every thought, every action, has a mechanism produced in a chemical “machine” called a brain. Distortions are the result of a combination of cellular energy deficiency (malnutrition), coupled with a potential genetic risk and perhaps a stress factor such as an otherwise mild infection/injury, or an inoculation. Any one of the three factors may dominate the clinical presentation, but in most cases the other two are involved.

A New Model: Genetics, Nutrition, and Stress

Throughout life each of us depends on our ability to survive in an essentially hostile environment. The first thing that it depends upon is our genetic inheritance that I have called “the blueprint”. But we also know that the “engines” of our cells, known as mitochondria, have their own genes in which the DNA is more susceptible to damage than our cellular genes. A new model must consider the fact that any stress requires energy in an adaptive response to any form of environmental attack resulting from a mental or physical problem or infection. The only way that we can protect the structural components of our bodies is by the use of the natural ingredients of nutrition, the ancient teaching of Hippocrates. The new science of epigenetics finds evidence that nutrition and lifestyle can make changes to our genes that might be beneficial or not, according to the circumstances. If a person has become sick from an excess of empty calories and refuses to change, the only way to treat that person would be by increasing the concentration of the missing nutritional ingredient in the form of a supplement. It is of paramount interest that in 1962 a paper was written in a prestigious medical journal. The author had found 696 medical journal manuscripts that reported 250 different diseases that had been treated with supplementary thiamine, with varying degrees of success. This suggests the possibility that health is produced by a combination of genetic influence, how we meet the daily impacts of stress and the quality of our nutrition. Disease results from, either genetic failure (cellular or mitochondrial), failure to meet stress because of energy deficiency, malnutrition, or combinations of the three elements.

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Manifestations of Thiamine Deficiency: Another Case of Beriberi in America

by Derrick Lonsdale MD, FACN, CNS

Published on August 14, 2017

18.2K views

Why Publish Another Case?

Just last week, we published a case of classic beriberi in a 23 year old man, and now, yet another case comes to our attention. Most in the medical profession are under the false impression that beriberi, thiamine deficiency, has been eradicated in Western cultures. It has not. In fact, a number of factors in modern Western culture have aligned to make thiamine sufficiency more precarious than ever. High calorie malnutrition and toxicant exposures are top among them. For a detailed look at thiamine deficiency in modern cultures, see our new book: Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition.

Kaleidoscope of Symptoms Associated with Thiamine Deficiency

There are a colossal number of symptoms associated with thiamine deficiency. The symptoms are confusing and not being seen for what they represent. First of all, let me make it clear: we are oxygen consuming animals and anything that interferes with oxygen utilization in the body will produce symptoms that are called to our attention by the brain and demand explanation. Any adverse sensation whether it be pain, itching or any other symptom is expressly a result of brain action. Joint pains are not perceived in the joints. They are perceived in the brain, even though the joint is actually the location of the inflammation.

The body consists of 70 to 100 trillion cells, all of which have to cooperate in producing human function. Each of these cells requires energy that is developed in specialized organelles within each cell. These organelles are called mitochondria and the way that they produce the required energy is by the combination of oxygen with glucose. Known as oxidation, thiamine is a major catalyst in this process and can be compared to a spark plug in a car cylinder. No gasoline (glucose), no function. No oxygen, no function. No spark plug (thiamine), no function. If oxidation in the mitochondria is compromised, the function of the cell in which they reside is also compromised. Because the brain and heart are the highest oxygen consuming organs in the body, it is not particularly surprising that these organs are the most affected in the disease called beriberi.

Please remember that this is an extremely ancient disease for which no cause was known for centuries. The word beriberi, according to the Oxford English dictionary, comes from a Sinhalese phrase meaning “weak, weak” or “I cannot, I cannot”, the word being duplicated for emphasis. I think of the body as being like an orchestra. Every organ knows exactly what it has to do, but its action must be monitored by the brain which acts as the conductor in playing “the Symphony of Health”.

A Case of Unrecognized Beriberi

The woman whose symptoms are discussed here is 38 years of age. During childhood she experienced what she called a great deal of pain, repeated episodes of candida infection (yeast) breathing trouble with swimming and running, reactive hypoglycemia, chest pain, panic attacks and nausea. She has recently experienced dizziness.

How Was She Treated?

Because the many physicians that she has seen were unable to find significant laboratory changes, the symptoms were usually explained as “it is all in your head”. This is really a pejorative diagnosis because it is assuming that the unfortunate patient is either inventing the symptoms or experiencing them in her imagination. The paradox is that the symptoms are produced in the brain by abnormal signals between the brain and body organs. They are just as real as any other symptom where there is physical evidence of its cause.

Modern medicine seems to think in extraordinarily limited terms and prednisone is offered for many different symptoms as it was in this case. Prednisone made her symptoms worse as indeed it often does. Dizziness was treated by a chiropractor by an “adjustment of the Atlas” (the first bone in the neck that supports the skull) and made her worse. She was found to have scoliosis of the spine and without going into details, this is because of compromised oxidation in the brainstem. It results in asymmetric motor signals to the muscles on either side of the spine, producing the typical curvature.

Understanding the Clinical Clues

The symptoms in childhood indicated even then oxidation was inefficient.

Difficulty breathing. She had breathing trouble when swimming or running, indicating that the breathing control mechanisms in the brain were affected.

Reactive hypoglycemia. She consumed a great deal of sugar and reported reactive hypoglycemia, a classical effect of thiamine deficiency caused by the excessive sugar. It results in overproduction of insulin, hence the drop in blood sugar.

Digestive problems. She reported “stomach problems” in pregnancy, gastritis and GERD, all of which can occur with thiamine deficiency.

Panic attacks. Chest pain, panic attacks and nausea are all related to brain oxygen compromise.

Nystagmus. Her dizziness, reported to be associated with “vertical downbeat nystagmus” are both typical of beriberi.

Yeast infections and Brewer syndrome. She had repeated episodes of yeast infection. This is an opportunist organism, meaning that it is detecting a body situation which is favorable to it and not to its host. Of course, yeast is used to create alcohol from sugar and the squeaks and bubbles experienced by the patient represent the effects of ongoing fermentation in the bowel. So her complaint of “constantly feeling drunk” is quite real and is known as the Brewer syndrome.

Connecting the Dots: The Myriad Manifestations of Thiamine Deficiency

The history in this woman indicates that her health problems existed in childhood and may well have started because of her mother’s pregnancy. She indicated that she consumed a great deal of sugar, by far and away the easiest way to produce thiamine deficiency. The nystagmus and dizziness are manifestations of oxidative dysfunction in the brain and indicate the ongoing problem. There may well be a genetic mechanism involved. However, the genetic mechanism can be mild enough not to result in symptoms unless nutrition and stress events are involved. She reported that she had experienced a number of surgical interferences, each one of which may have been sufficient stress to initiate downgrading in her thiamine deficiency. We now know that a marginal deficiency can be converted into full-blown deficiency as a result of the energy consumption required in meeting the stress.

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Just Released: Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition

by Chandler Marrs, PhD

Published on August 10, 2017

10K views

Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition

Together with Dr. Lonsdale, I am proud to announce the release of our new book: Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition.

If you have followed our blog, Hormones Matter, for any amount of time, you’ll know that we spend a lot time writing about mitochondrial distress. Mitochondria are the engines that fuel our cells and sit at the nexus of health and disease. Healthy mitochondria do much to stave off disease, allowing the body to survive all manner of modern stressors, from illness to toxicant exposures, and everything in between. Unhealthy mitochondria, on the other hand, can set into motion a series of reactions leading to complex, multisystem illnesses that modern medicine often has no earthly idea how to treat. This book is about those illnesses and the mitochondrial cascades that allow their existence.

We cover the chemistry of illness from the mitochondria upwards through the autonomic system, to the symptoms and back again. It is a chemistry that we seem to have forgotten in recent years, a chemistry we like to ignore when it contradicts our presumptions about pharmaceutical medicine and diet, and a chemistry that kicks us in the butt when we deny its importance. The chemistry is complicated on its surface, but a deeper dive reveals what Dr. Lonsdale refers to as ‘the exquisite simplicity‘ of health and disease. This book will teach you that chemistry and much more.

Why Thiamine? Why Now?

Thiamine takes center stage in this book, not because it is a magic vitamin that cures all, but because it sits atop the mitochondrial energy pathways. It is a gatekeeper of sorts, determining if or how other downstream mitochondrial functions proceed. For some inexplicable reason, amid all the research on the importance of other nutrients, we seem to have forgotten thiamine. Over and over again, we are presented with cases on Hormones Matter of overt thiamine deficiency, and yet, rarely do physicians consider it. More often than not, it is the patients or their caregivers that figure it out.

Why don’t we consider one of the most fundamental units of health? The short answer, if we are honest with ourselves, pharmacology and surgery are far sexier than nutrition. Unfortunately, however, disease processes do not develop because of drug deficiencies or a lack of surgical prowess. In the Western world, they develop in large part because of nutrient deficiencies within the context of high calorie malnutrition and in conjunction with other stressors. Understanding the chemistry that decides health or disease is critical to achieving health. A key component of that chemistry involves thiamine. This book details how to recognize, evaluate, treat, and understand thiamine deficiency. It is a complicated topic, but written for a broad audience.

Buy Now and Receive a Discount

For a limited time, the publisher is offering a 30% discount off of the list price and free shipping if the book is ordered from their site. Just click the link below enter the promotional code ATR30 at checkout.

Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition

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Adverse Reactions, Hashimoto’s Thyroiditis, Gait, Balance and Tremors

by Chandler Marrs, PhD

Published on July 6, 2017

77.6K views

Gait, tremors with adverse medication vaccine reactions

One of the things I most love about social media and health research is the opportunity to identify patterns of illness across different patient groups. Here is an example of finding research from one patient group, ThyroidChange, that likely spans many others (Gardasil injured, post Lupron Hashimoto’s, and Fluoroquinolone reactions – to name but a few) and offers clues to a perplexing array of symptoms. The research, is about a little known association between movement and balance disorders and Hashimoto’s thyroiditis: Ataxia associated with Hashimoto’s disease: progressive non-familial adult onset cerebellar degeneration with autoimmune thyroiditis. Some background.

Hashimoto’s Disease

Hashimoto’s is the most common causes of hypothyroidism afflicting women at a rate of 10 to 1 compared to men. It is an autoimmune disorder in which antibodies attack the thyroid gland and destroy its ability to maintain normal thyroid hormone concentrations. The most common symptoms include: fatigue, muscle pain, weight gain, depression, cognitive difficulties, cold intolerance, leg swelling, constipation, dry skin. If left untreated, goiter – a swollen thyroid gland, appears. If left untreated for an extended period, cardiomyopathy (swelling of the heart muscle), pleural (lung) and pericardial (heart) effusion (fluid), coma and other dangerous conditions develop.

Hashimoto’s and Cerebellar Degeneration

A little known risk in Hashimoto’s is cerebellar degeneration. The cerebellum is the cauliflower looking section at the base of the brain that controls motor coordination – the ability to perform coordinated tasks such as walking, focusing on a visual stimuli and reaching for objects in space. The walking and balance disturbances associated with cerebellar damage or degeneration have a very distinct look, a wide gait, with an inability to walk heel to toe. Cerebellar ataxia looks like this:

In recent years, cerebellar involvement in attention and mood regulation have also been noted. The physicians reporting the Hashimoto’s – ataxia connection present case studies of six patients with Hashimoto’s disease, presumably controlled with medication and a progressive and striking shrinkage of the cerebellum (see report for MRI images) along with progressively debilitating ataxia (walking and balance difficulties) and tremors. Here’s where it becomes interesting.

Hashimoto’s: Medication Adverse Reaction and Misdiagnosis

Hashimoto’s disease is prevalent in our research into medication adverse reactions for Gardasil and Cervarix and Lupron, with some indications it may develop post Fluoroquinolone injury as well. The symptoms are difficult to distinguish from other neurological and neuromuscular diseases such as chronic fatigue syndrome, fibromyalgia, multiple sclerosis and an array of psychiatric conditions, and so Hashimoto’s often goes undiagnosed or is misdiagnosed and mistreated for some time.

Hashimoto’s, Demyelination and Cerebellar Damage

In some of the more severe adverse reactions to medications and vaccines that would lead to Hashimoto’s, the tell tale cerebellar gait disturbances have been noted and documented, along with a specific type of tremor (discussed below).

Research from other groups shows a strong relationship between thyroid function and myelin/demylenation patterns in nerve fibers in animals. Specifically, insufficient T3 concentrations demyelinates nerve axons, while T3 supplementation elicits myelin regrowth. Myelin is the white sheathing, the insulation that protects nerves and improves the electrical conduction of messages in sensory, motor and other neurons. Like co-axial cable in electrical wiring, when the protective sheathing is lost, electrical conductance is disrupted. The early symptoms of a demyelinating disease neuromuscular pain, weakness, sometimes tremors. These can be misdiagnosed as multiple sclerosis, fibromyalgia, chronic pain, when in reality, the culprit is a diseased thyroid gland.

Back to the Cerebellum

The cerebellum is a focal point of white matter axons – myelinated sensory and motor nerves. The cerebellum is where input becomes coordinated into motor movements or movement patterns. White matter damage in the cerebellum causes cerebellar ataxia, the movement and balance disorders displayed above. Hashimoto’s elicits white matter disintegration. Adverse reactions to medications and vaccines can elicit autoimmune Hashimoto’s disease. See the connection?

The Thiamine – Gut Connection

It gets even more interesting when we add another component of systemic medication adverse reactions – nutritional malabsorption, specifically thiamine deficiency. Almost across the board, patients with medication or vaccine adverse reactions report gut disturbances, from leaky gut, to gastroparesis, constipation, pain and a myriad of other GI issues that make eating and then absorbing nutrients difficult. Gut issues are common in thyroid disease too.

As we learn more, and as individuals are tested, severe nutrient deficiencies are noted, in vitamin D, Vitamin B1, B12, Vitamin A, sometimes magnesium, copper and zine. We’ve recently learned of the connections between Vitamin B1 or thiamine deficiency and a set of conditions affecting the autonomic nervous system called dsyautonomia or Postural Orthostatic Tachycardia Syndrome (POTS) linked to thiamine deficiency in the post Gardasil and Cervarix injury group. It may be linked to other injured groups as well, but we do not know yet.

Thiamine and Cell Survival

Thiamine or vitamin B1, is necessary for cellular energy. It is a required co-factor in several enzymatic processes, including glucose metabolism and interestingly enough, myelin production (the Hashimoto’s – cerebellar connection). We can get thiamine only from diet. When diet suffers as in the case of chronic alcoholism, where most of the research on this topic is focused, or when nutritional uptake is impaired, thiamine deficiency ensues. Thiamine deficiency can elicit cell death by three mechanisms:

Mitochondrial dysfunction (reduced energy access) and cell death by necrosis
Programmed cell death – apoptosis
Oxidative stress – the increase in free radicals or decrease in ability to clear them

Thiamine deficiency in and of itself can elicit a host of serious health symptoms. The cell death and disruption of cellular energy balance can be significant and lead to a totally disrupted autonomic system.

Thiamine and Myelin Growth

Add to those symptoms, the fact that thiamine is involved in the growth myelin sheathing around nerves, and we have a whole host of additional neuromuscular symptoms masking as fibromyalgia, multiple sclerosis, chronic fatigue. Like with MS, limb and body tremors are noted in dysautonomic syndromes such as POTS. (Video of POTS tremors, note the uniqueness of the POTS tremor and the similarity between it and the foot tremor shown above along with cerebellar ataxia).

Let thiamine deficiency continue unchecked for period and we get brain damage, as white matter – the myelin disintegrates in the brainstem, the cerebellum and likely continues elsewhere. One of the most prominent areas of damage in thiamine deficiency, is the cerebellum, and hence, the cerebellar ataxia (movement disorders) noted in chronic alcoholics who are thiamine deficient, but also observed post medication or vaccine adverse reaction.

The Double Whammy on Myelin and Cerebellar Function

In the case medication or vaccine adverse reactions, particularly those that reach the systemic level, we have a double whammy on myelin disintegration: from a diseased thyroid gland and a diseased gut. Hashimoto’s and the reduction of thyroid hormones, particularly T3, impairs nerve conduction by shifting from a constant and healthy remyelinating pattern to one of demyelination, while the lack of thiamine further impairs myelin regrowth, because it is a needed co-factor. Both deficiencies affect peripheral nerves, but both also hit the brainstem, the cerebellum and likely other areas within the brain.

Take Home Points

The science of adverse reactions is new and evolving and much of what I am reporting here remains speculative. However, it has become abundantly clear through our research that to address medication adverse reactions or vaccine adverse reactions in a simplistic fashion, by region, or in an organ specific manner, is to miss the broader implications of the compensatory disease processes that ensue. Moreover, to look for symptoms of adverse reactions simply by the drug’s mechanism of action and/or by the standard outcome variables listed in adverse event reporting systems, again misses the complexity of the human physiological response to what the body is perceiving as a toxin. I believe that the entire framework for understanding the body’s negative response to a medication must be shifted to a much broader, multi-system, and indeed, multidisciplinary approach. In the mean time, we will continue to collect data on adverse reactions and offer our readers points of consideration in their quests for healing. I should note, that finding these connections is entirely contingent on the input our community of patients and health activists, both via the personal health stories that so many of you have been willing to share and the data we collect through our research. You know more about your health and illness than we do.

What we Know So Far – Tests to Consider

If you have had an adverse reaction to a medication or vaccine and neuromuscular difficulties, like pain, numbness, motor coordination problems, tremors etc., consider testing for Hashimoto’s thyroiditis. Also, consider thyroid testing when fatigue, depression, mood lability (switching moods), constipation, attentional and focus difficulties are present. In fact, I would consider thyroid testing, specifically for autoimmune thyroid disease like Hashimoto’s, as one of the first disease processes to rule out.

If you have had an adverse reaction to a medication that includes gut disturbances, consider the possibility that you are deficient in key micronutrients such as Vitamin D, the B’s, Vitamin A, magnesium, copper, zinc. And given the modern diet, consider that you were probably borderline deficient even before experiencing the adverse reaction. These nutrients are critically important to health and healing (and no, I do not have an association with vitamin companies or testing companies). Some tests for these nutrients are more accurate than others, so be sure to do your homework first.

If you have symptoms associated with autonomic systems dysregulation such as those associated with POTS, dysautonomia and its various permutations, consider thiamine testing, especially, transkelotase testing.

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Postscript: This article was published originally on Hormones Matter on October 15, 2013.

What is Thiamine to Energy Metabolism?

by Derrick Lonsdale MD, FACN, CNS

Published on June 26, 2017

12K views

What is Energy?

Energy is an invisible force. The aggregate of energy in any physical system is a constant quantity, transformable in countless ways but never increased or diminished. In the human body, chemical energy is produced by the combination of oxygen with glucose. This reaction is known as oxidation. The chemical energy is transduced to electrical energy in the process of energy conservation. This might be thought of as the “engine” of the brain/body cells. We have to start thinking that it is electrical energy that drives the human body. The production of chemical energy is exactly the same in principle as the burning of any fuel but the details are quite different. The energy is captured and stored in an electronic form as a substance known as adenosine triphosphate (ATP) that acts as an energy currency. The chemical changes in food substances are induced by a series of enzymes, each of which combine together to form a chain of chemical reactions that might be thought of as preparing food for its ultimate breakdown and oxidation. Each of these enzymes requires a chemical “friend”, known as a cofactor. One of the most important enzymes, the one that actually enables the oxidation of glucose, requires thiamine and magnesium as its cofactors. Chemical energy cannot be produced without thiamine and magnesium, although it also requires other “colleagues”, since all vitamins are essential. A whole series of essential minerals are also necessary, so it is not too difficult to understand that all these ingredients must be obtained by nutrition. The body cannot make vitamins or essential minerals. There is also some evidence that thiamine may have a part to play in converting chemical energy to electrical energy. Thus, it may be the ultimate defining factor in the energy that drives function. If that is true, its deficiency would play a vital role in every disease.

Energy Consumption

Few people are aware that our lives depend on energy production and its efficient consumption. A car has to have an engine that produces the energy. This is passed through a transmission that enables the car to function. In a similar manner, we have discussed how energy is produced. It is consumed in a series of energy requiring chemical reactions, each of which requires an enzyme with its appropriate cofactor[s]. This series of reactions can be likened to a transmission, enabling the human body to function. If energy is consumed faster than it can be synthesized, or energy cannot be produced fast enough to meet demand, it is not too difficult to see that it would produce a fundamental change in function. Lack of function in body organs affects our health. The symptoms are merely warning the affected individual that something is wrong. The underlying cause has to be ascertained in order to interpret how the symptoms are generated.

Why Focus on Thiamine?

We have already pointed out that thiamine does not work on its own. It operates in what might be regarded as a ”team relationship”. But it has also been determined as the defining cause of beriberi, a disease that has affected millions for thousands of years. Any team made up of humans requires a captain and although this is not a perfect analogy, we can regard thiamine as “captain” of an energy producing team. This is mainly due to its necessity for oxidation of glucose, by far and away the most important fuel for the brain, nervous system and heart. Thus, although beriberi is regarded as a disease of those organs, it can affect every cell in the body and the distribution of deficiency within that body can affect the presentation of the symptoms.

Thiamine exists only in naturally occurring foods and it is now easy to see that its deficiency, arising from an inadequate ingestion of those foods, results in slowing of energy production. Because the brain, nervous system and heart are the most energy requiring tissues in the body, beriberi produces a huge number of problems primarily affecting those organs. These changes in function generate what we call symptoms. Lack of energy affects the “transmission”, giving rise to symptoms arising from functional changes in the organs thus subserved. However, it must be pointed out that an enzyme/cofactor abnormality in the “transmission” can also interrupt normal function.

In fact, because of inefficient energy production, the symptoms caused by thiamine deficiency occur in so many human diseases that it can be regarded as the great imitator of all human disease. We now know that nutritional inadequacy is not the only way to develop beriberi. Genetic changes in the ability of thiamine to combine with its enzyme, or changes in the enzyme itself, produce the same symptoms as nutritional inadequacy. It has greatly enlarged our perspective towards the causes of human disease. Thiamine has a role in the processing of protein, fat and carbohydrate, the essential ingredients of food.

Generation of Symptoms

Here is the diagnostic problem. The earliest effects of thiamine deficiency are felt in the hindbrain that controls the automatic brain/body signaling mechanism known as the autonomic nervous system (ANS). The ANS also signals the glands in the endocrine system, each of which is able to release a cellular messenger. A hormone may not be produced in the gland because of energy failure, thus breaking down the essential governance of the body by the brain. Hypoxia (lack of oxygen) or pseudo-hypoxia (thiamine deficiency produces cellular changes like those from hypoxia) is a potentially dangerous situation affecting the brain and a fight-or-flight reflex may be generated. This, as most people know, is a protective reflex that prepares us for either killing the enemy or fleeing and it can be initiated by any form of perceived danger. Thus, thiamine deficiency may initiate this reflex repeatedly in someone that seeks medical advice for it. Not recognizing its underlying cause, it is diagnosed as “panic attacks”. Panic attacks are usually treated by psychologists and psychiatrists with some form of tranquilizer because of the anxiety expressed by the patient. It is easy to understand how it is seen as psychological, although the sensation of anxiety is initiated in the brain as part of the fight-or-flight reflex and will disappear with thiamine restoration. It may be worse than that: because the heart is affected by the autonomic nervous system, there may be a complaint of heart palpitations in association with the panic attacks and the heart might be considered the seat of the disease, to be treated by a cardiologist. The defining signal from the ANS is ignored or not recognized. Because it is purely a functional change, the routine laboratory tests are normal and the symptoms are therefore considered to be psychological, or psychosomatic. The irony is that when the physician tells the patient “it is all in your head”, he is completely correct but not recognizing that it is a biochemical functional change and that it has nothing to do with Freudian psychology.

A Sense of Pleasure

A friend of mine has become well aware that alcohol, in any form, or sugar, will automatically give him a migraine headache. He still will take ice cream and suffer the consequences. I have had patients tell me that they have given up this and that “but I can’t give up sugar: it is the only pleasure that I ever get”. They still came back to me to treat the symptoms. We have come to understand that we have no self-responsibility for our own health. If we get sick, it is just bad luck and the wonders of modern medicine can achieve a cure. The trouble is that a mild degree of thiamine deficiency might produce symptoms that will make it more difficult to make the necessary decisions for our own well-being. Let me give some examples of symptoms that are typically related to this and are not being recognized.

Occasional headache
Occasional heartburn or abdominal pain
Occasional diarrhea or constipation
Allergies
Fatigue
Emotional lability
Insomnia
Nightmares
Pins and needles
Hair falling out
Heart palpitations
Persistent cough for no apparent reason
Voracious or loss of appetite

The point is that thiamine governs the energy synthesis that is essential to our total function and it can affect virtually any group of cells in the body. However, the brain, heart and nervous system, particularly the autonomic (automatic) nervous system (ANS) are the most energy requiring organs and are likely to be most affected. Since the brain sends signals to every organ in the body via the ANS, a distortion of the signaling mechanism can make it appear that the organ receiving the signal is at fault. For example, the heart may accelerate because of a signal from the brain, not because the heart itself is at fault. Hence, heart palpitations are often treated as heart disease when a mild degree of thiamine deficiency in the brain is responsible. We have known for many years that sugar in all its different forms can and will precipitate mild thiamine deficiency. It is probably the reason why sugar is considered to be a frequent cause of trouble. If thiamine deficiency is mild, any form of minor stress may precipitate a much more serious form of the deficiency.

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Post Gardasil Heart Failure, Ragged Red Fibers and Thiamine

by Derrick Lonsdale MD, FACN, CNS

Published on March 29, 2017

13.9K views

I recently became aware of a case of a boy who had died from a myocarditis and subsequent heart failure after he had received the Gardasil vaccination. He was reportedly completely healthy before the vaccination and the death had been directly attributed to it. The autopsy report was very striking. Examination of heart muscle had revealed a “long narrow band of dark reddish discoloration, somewhat darker than the rest of the myocardium”. Although this was not described more fully, it strongly suggested that the description was that known in medical jargon as “ragged red fibers”.

Ragged red fibers are commonly seen with mitochondrial dysfunction in muscle tissue. The ragged red fibers indicate an accumulation of abnormally functioning mitochondria in the muscle tissue. Though ragged red fibers have been studied extensively in individuals with inherited mitochondrial disease, it is not clear whether this type of damage can be acquired or induced in individuals with or even without mtDNA mutations. Studies in rats, however, have shown that thiamine deficiency does result in the finding of ragged red fibers in muscle tissue, suggesting that this damage can be induced. In view of the many posts on this website discussing the association of thiamine deficiency with Gardasil vaccination, I became very interested and began to search the literature for what was known about the relationship of thiamine with ragged red fibers.

Mitochondria

Before I offer an explanation, let me remind the reader about mitochondria. We have between 70 and 100 trillion cells that make up the human body. Each cell has a prescribed function and each of the body organs consist of highly specialized cells. What we tend to forget is that our food provides the fuel from which energy is generated. To use a simple analogy, a car without an engine would not be capable of functioning. Mitochondria are the “engines” that exist in each one of those cells. They provide the energy for which function is dependent. We inherit from our parents thousands of genes that control how we look, behave and perform as personalities. These are known as cellular genes, but mitochondria have entirely separate genes inherited only from the mother. They control the mechanisms of the “engines” (mitochondria) in generating energy. Disease can be caused by genetic mutations in cellular genes but in the past decade it has been recognized that mitochondrial genes can be responsible for disease and more than 50 different mutations have been described. The majority of these mutations are single base changes in the DNA strand. They do not necessarily produce disease by themselves. Other factors related to nutrition, lifestyle, and as I suspect, medications and vaccines, may have to come into play.

To express this fully, a deficiency of thiamine (or other vitamins) can be so mild that the symptoms, if any, are regarded as inconsequential or ascribed to other causes. This obviously becomes more important if there is an associated unknown genetic risk that affects the metabolism of the vitamin. Because thiamine is so vital to energy synthesis, the imposition of a stress factor such as a mild infection or an inoculation can precipitate more severe symptoms. Meeting stress requires adaptive energy. To provide an analogy, a car with an inefficient engine may be adequate on the level but be inadequate to meet the stress of climbing a hill.

Mitochondrial Disorders are Multi-Systemic

I should note that mitochondrial disorders are often multi-systemic due to impaired oxidation that results in defective mitochondrial energy production. That means there can be symptoms from damage to multiple organ systems simultaneously. Mitochondrial disorders are also phenotypically different amongst family members with the same mutation and amongst individuals with acquired mitochondrial dysfunction. In other words, how mitochondrial disorders or damage can present symptomatically varies radically from person to person. This variation is what makes diagnosing mitochondrial dysfunction difficult for many practitioners. The symptoms don’t always fit into nice, neat, discrete diagnostic categories that so many of us are accustomed too. This variability in mitochondrial dysfunction makes it difficult to attribute the action of a vaccine or medication as the cause of a subsequent illness, or in some cases, death. How is it possible for a medication or vaccine to induce so many seemingly disparate symptoms? To answer that question, we need to understand a few mechanisms.

Thiamine Deficiency Post Gardasil

Over the last several years, we have identified several cases of laboratory confirmed thiamine deficiency post Gardasil. Additionally, when lab testing was unavailable (few labs offer the appropriate assays for thiamine testing), clinical response to thiamine treatment has been confirmatory. In more recent research, we have identified thiamine transporter gene mutations (SLC19A2) in a group of young women who experienced severe reactions to the Gardasil vaccine (reported within this article). Combined, this suggests that thiamine deficiency is involved in some of the adverse reactions observed and that the potential danger from the use of a vaccine requires more information from the patient and his/her family. How can something as simple as thiamine cause so many adverse reactions and even death? And can a medication or vaccine induce thiamine deficiency?

Thiamine is Critical for Mitochondrial Functioning

Thiamine is a critical co-factor in multiple pathways involved in mitochondrial energy production (ATP). It is necessary for carbohydrate processing via the pyruvate pathway and it is necessary for fatty acid processing because of its involvement with the HACL1 enzyme. In other words, the mitochondria depend upon thiamine to function. Diminish thiamine and all sorts of compensatory reactions are initiated which, if not stopped, can cause death. Thiamine deficiency in adults, particularly those with chronic alcoholism, is considered a medical emergency. It has not, however, been readily recognized in reference to other causes of malnutrition where there is an imbalance between the ingested calories and the necessary vitamins – high calorie malnutrition. This particularly applies to thiamine.

The Gardasil Thiamine Relationship

There are multiple mechanisms by which a vaccine or medication can induce thiamine deficiency or push an existing or subclinical deficiency into a danger zone. Beginning with the later first, the modern western diet is replete with highly processed foods that are dense in calories but lack non-caloric nutrients. It is entirely likely that many individuals, even those that appear healthy, are borderline thiamine deficient or intermittently thiamine deficient when stressors or illnesses arise. Vaccines are toxicological stressors to the immune system and broadly speaking, any stressor, but particularly one that demands an immune reaction like a vaccine, is capable of inducing a thiamine deficient state. In individuals with latent errors in thiamine absorption (GI disorders), distribution or metabolism (like those with thiamine transporter mutations), or anything that evokes even a slight degradation in thiamine nutrient availability, thiamine deficiency will be exacerbated exponentially.

The Gardasil vaccine was developed using a yeast type base*. The yeast produces an enzyme called thiaminase that inactivates thiamine. Again, against the backdrop of poor diet or diet high in foods that also produce thiaminase (coffee, tea, certain fish), but especially, against the backdrop of a genetic or acquired mitochondrial issue recognized or latent, the reaction to the vaccine (or medication, as many medications can block thiamine directly or indirectly), can be devastating.

Finally, vaccines, because of the adjuvant carriers like aluminum, damage to mitochondrial functioning more broadly, with both structural and functional changes are noted. Damaged mitochondria are not only less capable of producing appropriate amounts of cellular energy but are also incapable of performing the myriad of other functions with which the mitochondria are tasked.

Ragged Red Fibers and Cardiomyopathy

Let us continue with this case and the ragged red fibers observed in the myocardium, the heart muscle, of the deceased boy. For those who study mitochondrial disorders, one of the more common histological hallmarks of the disease process in mitochondrial disorders are ragged red fibers. These are muscle fibers with abnormal focal accumulations of mitochondria. According to the coroner’s report:

“a long narrow band of dark reddish discoloration which is somewhat darker than the rest of the myocardium, extends over a length of 6 cm and has a width of 0.4 cm extending from the anterior base of the heart almost to the apex. ..this lesion is limited to the anterior free wall”

was observed. The coroner concluded that the boy developed asymptomatic myocarditis in weeks preceding his death. The myocarditis evoked a heart attack which was the determined cause of death. A subsequent review by a medical expert hired by the attorneys presenting the case against the vaccine manufacturer, went a little deeper, attributing the dark fibers to a vaccine-induced inflammatory reaction resulting from the first dose of Gardasil. He argued that the first dose of the vaccine initiated a heart attack that was somehow not noticed by the child, as he continued to play football. Upon receiving the second dose, however, the damage initiated by the first dose was exacerbated, slowing heart function until it failed entirely. In either case, the heart muscle was irreparably damaged such that the child died in his sleep with the Gardasil as the causal agent.

Given my background in thiamine research, and thiamine’s role in heart function (as well as in brain function), I immediately wondered if the observed “band of darkish reddish discolorations” could be the ragged red fibers so common in mitochondrial dysfunction and if there presence indicated thiamine deficiency. Furthermore, I suspected that the fact that he died in his sleep strongly suggested that the automatic respiratory mechanism governed by the brain stem was implicated. This too, is a strong support for thiamine deficiency. I should note, I did not have access to the full report; only that which was published online.

Thiamine Deficiency and Ragged Red Fibers: Experimental Evidence

As I have argued previously and elaborated above, the HPV vaccines can induce and/or exacerbate thiamine deficiency. The question is whether thiamine deficiency can induce ragged red fibers in muscle.

To that end, I discovered a manuscript in the Archives of Neurology: Neuropathic and mitochondrial changes induced in rat muscle, showing that experimentally in rodents this was possible. Thiamine deficiency could induce ragged red fibers in muscle tissue. In this particular study, two groups of rats were compared. One group was fed a normal diet and the other group was fed a diet deficient in thiamine. The rats with thiamine deficient diets developed ragged red fibers in the muscles. Other abnormalities were described not found in the muscles of the control rats. The authors concluded that thiamine deficiency was responsible for the observed ragged red fibers and may be involved in what are now called the “ragged-red diseases”.

Case Studies: Ragged Red Fibers, Thiamine and Mitochondrial Disease

Japanese investigators studied two siblings with muscle disease due to mitochondrial dysfunction, a mutation in the mitochondrial DNA, and familial thiamine deficiency. Ragged red fibers were found in muscle biopsies. The older brother had presented at the age of 20 years when he developed muscle disease and beriberi heart disease. Thiamine deficiency was present in the siblings and parents and ragged red fibers were noted in muscle biopsies from the siblings. The development of symptoms at the age of 20 years certainly indicates that it was not a purely genetically determined disease.

Another article in a Japanese journal reported a nine year-old boy with muscle and brain disease in whom thiamine administration gave temporary improvement. A muscle biopsy had revealed numerous ragged-red fibers.

Mitochondrial diseases have a special predilection to involve the brain in view of its high metabolic demand. Patients with a form of disease known as myoclonic epilepsy have ragged red fibers in muscle tissue thus identifying the underlying mitochondrial cause.

Mitochondrial Dysfunction in Myocardial Infarction and Sudden Death

In a recent review of mitochondrial cardiomyopathies we see some striking similarities between this case and what has been recently recognized. Accordingly:

The presentation of mitochondrial cardiomyopathy includes hypertrophic, dilated, and left ventricular (LV) noncompaction, and the severity can range from no symptoms to devastating multisystemic disease. Severe cardiac manifestations include heart failure and ventricular tachyarrhythmia—which can worsen acutely during a metabolic crisis —and sudden cardiac death. Mitochondrial crisis is often precipitated by physiologic stressors such as febrile illness or surgery [a vaccine] and can be accompanied by acute heart failure.
Bioenergetic derangements are increasingly recognized as major culprits in the development of cardiac hypertrophy and in the progression to heart failure, in both acquired and inherited disease. The mitochondria are a crucial platform for energy transduction, signaling, and cell-death pathways that are broadly relevant to heart failure, even in the absence of an underlying mitochondrial myopathy. Oxidative stress and mitochondrial dysfunction are key factors in the development of most heart failure.

Connecting the Dots

The question remains, how could this boy’s death from a vaccination have been predicted and thus avoided? It is clear that there was temporal relationship between the vaccine, the damage to his heart, and his subsequent death. Mechanistically, the evidence is collaborative with this association. From an evidentiary standpoint, the vaccine appears capable of inducing mitochondrial dysfunction via its ability to diminish thiamine, and likely, via other, yet to be identified, mechanisms. Of key importance, however, is that thiamine depletion on its own, can induce ragged red fibers in muscle tissue, probably including the heart muscle. When the vaccine is given to an individual with genetic or other risk factors (like comorbid health issues, poor diet, and/or the high metabolic demands of sports training), the results can be devastating. Given that this combination of variables includes most teenagers, it is difficult not to see the dangers of this vaccine. In conclusion, if the long band of dark reddish muscle tissue described in the heart muscle of the boy had been shown to be ragged red fibers, it would have supported mitochondrial dysfunction as the cause of death.

*It should be noted that the Cervarix HPV vaccine was not developed using a yeast base, and thus, it is not clear by what mechanism(s) it might diminish thiamine concentrations.

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Image: Very high magnification micrograph showing ragged red fibres (also ragged red fibers), commonly abbreviated RRF, in a mitochondrial myopathy. Gomori trichrome stain.

Nephron, CC BY-SA 3.0, via Wikimedia Commons

This article was published originally on Hormones Matter on January 5, 2016.

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