Ann Louise Gittleman Interviews Dr. Chandler Marrs

Everyone Needs a Little Extra Thiamine: New Podcast

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Several months ago, I had the great pleasure of speaking with Ann Louise Gittleman, an icon in women’s health and nutrition. The topic, as you might have guessed, was modern thiamine deficiency. We dive right into why so many of us are deficient in thiamine and why so few of us, physicians included, consider thiamine as a culprit to illness.

Thiamine deficiency is quite possibly the most important vitamin deficiency of modernity. It causes a long list of ailments that can be easily remedied if you know what to look for. It is so important, that we wrote about it: Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition and have hundreds of research articles and case stories on the topic published here.

Why is thiamine so important? Well, thiamine is absolutely fundamental to mitochondrial function, and if you don’t know already, mitochondrial function is absolutely fundamental to everything else. The mitochondria take components of the foods we eat and convert that into biological energy or ATP. ATP then fuels cell function – all cell function. Diminished ATP capacity or output, as one might imagine, causes all sorts of problems, many of which underly modern illness.

If thiamine is that important, why isn’t it among the first nutrients tested when illness sets in? That is a good question. Aside from the lack of economic drivers (why prescribe an inexpensive vitamin when you can prescribe an expensive pill), the only answer that makes sense is that most people think this deficiency is impossible without starvation or alcoholism. That is what the textbooks have told us for generations.

Since we live in an era of food abundance, where obesity reigns and where most foods are either fortified or enriched with some vitamins, it is difficult to imagine vitamin malnutrition. In reality though, many of the products we call food have been so adulterated that they carry with them more toxins and more calories than even the added vitamins can overcome. I have written about this on a number of occasions as well. Here is just one of those articles, but there are many more, if you search the website.

Or, you can just have a listen to this latest podcast here.

thiamine podcast


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Chandler Marrs MS, MA, PhD spent the last dozen years in women’s health research with a focus on steroid neuroendocrinology and mental health. She has published and presented several articles on her findings. As a graduate student, she founded and directed the UNLV Maternal Health Lab, mentoring dozens of students while directing clinical and Internet-based research. Post graduate, she continued at UNLV as an adjunct faculty member, teaching advanced undergraduate psychopharmacology and health psychology (stress endocrinology). Dr. Marrs received her BA in philosophy from the University of Redlands; MS in Clinical Psychology from California Lutheran University; and, MA and PhD in Experimental Psychology/ Neuroendocrinology from the University of Nevada, Las Vegas.


  1. Didn’t know where to ask this but….. I have almost completed my Thiamine therapy now down to only the 25 mg hydrochloride in my multi-vitamin but my question is I have been taking 3-4 grams of potassium and 1 gram of sodium for cramping, pain and energy. it’s working very well however I am not sure how to eventually get off the potassium…… what signs will tell me that I can discontinue the electrolytes?

    • 3-4 grams of potassium is recommended through diet especially if one has blood pressure related issues. The RDA for potassium is quite low and generally insufficient for most people. I would track my consumption of the electrolytes through foods using the app called Cronometer to see what your average intake is and then determine how much more or less you need from supplementation.

      • Thanks for your advice! It says I am getting around 5 grams on an average day. Maybe I am one of those people who needs more. Is there any danger of throwing something else besides sodium off balance by supplementing potassium long term?

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