thiamine fatigue pregnancy

High Dose Thiamine Healed My Fatigue. How Do I Navigate Pregnancy?

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Downward Spiral, Upward Hope, Asking Advice

The year 2020 marked a big change for a lot of people. For me, it meant a downward spiral into intense fatigue, brain fog, and heart palpitations. Healing came in increments over the next three years until I found thiamine, which expedited my healing in six months. Now, I am considering pregnancy, but I need your advice. How do I navigate taking megadoses of supplements while growing a baby? How do I know when my healing journey is “complete,” and does that mean my supplement regimen ought to change? Any and all comments are welcome!

How It Started

It was early 2020 when I returned from a vacation from Thailand and got a stomach bug somewhere along the way home. I rested in bed a couple of days and mostly recovered, but had a lingering burning sensation in my stomach for the next month or so. I then noticed my stool started to smell strange and I experienced bloating after some meals. I went to the gastroenterologist, and within a month they had done an endoscopy and discovered erosive gastritis. I was put on a proton-pump inhibitor (PPI) and sucralfate to coat my stomach.

Two weeks on these medications and I felt immense brain fog and extreme fatigue, so much so that I felt like I would fall over in my chair at work. The fatigue hit me like a ton of bricks– I slept throughout the night and forced myself to take naps, and nothing helped shake the overwhelming fatigue. I took a few weeks off of work and tried to rehab myself at home, eating as much healthy food as possible (I was tracking 3,000 calories a day, which I felt I must need to get healthy again). I tracked all of my nutrients in an app and made sure I hit (and exceeded) the RDA for every nutrient (with the help of supplements). Still, things were not improving much, and I couldn’t even walk one stretch of the block without being utterly exhausted. It was during this time off of work where I felt so helpless and drained in every sense that I remember thinking, “this is what the beginning of dying feels like.” It scared me. But I honestly did not know what to do or where to turn.

A picture from July 2021 after a short hike. I felt horrible and my husband felt great :).

I knew the medications were not making me healthier (even if they made my stomach feel better), so I went off of them cold-turkey. The burning in my stomach became quite severe due to the rebound effect of getting off a PPI, but I pushed through, knowing that I needed my body to heal on its own.

The next three years brought incremental improvements, but still much suffering. Intense brain fog, insatiable fatigue that heightened post-exertion, and dysautonomic symptoms plagued me daily. I was waiting for a big break that seemed like it might never come. Little did I know, my time was coming in the spring of 2023.

How It Really Started

It would be easy to blame a stomach bug for all of my problems, but I now know that my nutrient stores have been taxed and depleted over many instances in my life. Here is a snippet of what led me to the crash:

– Childhood: Ear infections (antibiotics), chronic stomach aches, sugar consumption

– Adolescence: Traumatic brain injury (brain sheer, 3 days coma), mononucleosis, asthma

– Young adulthood: chronic UTIs (i.e., chronic antibiotics (including 3 separate Bactrim prescriptions and anti-fungals (fluconazole) afterward), several deaths in the close family (emotionally taxing), monthly naproxen for menstrual cramps, developed gluten sensitivity, shortness of breath (air hungry).

The stomach bug was simply the straw that broke the camel’s back. All of the stressors in my life (physical, emotional, etc.) depleted my body until it couldn’t retain a guise of “healthy” anymore.

My First (Unknowing) Megadose

Throughout the entirety of 2020, I experienced bloating and IBS symptoms. I managed the symptoms well enough with a low FODMAP diet, but one tiny piece of garlic, onion, etc. and I was ruined. I knew I wasn’t healed with this diet, but I didn’t really know how to heal, especially hearing that IBS is something you have to live with for the rest of your life. This scared me, but I wanted to see what answers may be out there.

I came across a study that claimed that the vast majority of participants taking a multivitamin, B-100 complex, and vitamin D3 were cured of their IBS within three months. It seemed like a miraculous and promising study, so I decided to try it myself. Lo and behold, around the three month mark, I was able to incorporate high FODMAP foods without experiencing bloating (it took a stretch of a few weeks to fully incorporate these foods as my body was adjusting).

Back then, I thought it was the vitamin B5 that was responsible for ridding me of bloating symptoms. Vitamin B5 is closely linked to gut health. Looking back now, I have a strong notion that I was helped due to the thiamine content in the B-100 + multivitamin. I megadosed without knowing it. And unfortunately, after about 4 months, I stopped taking the B-100.

My Second (Reluctant) Megadose

I visited a naturopath in the spring of 2021 to try to get more answers. I still had brain fog and fatigue, and had also developed a regular heart palpitation every ~15 minutes, which coincidentally happened after my second round of a certain vaccine. The naturopath prescribed many supplements, one of which was 150 mg of iron per day. I was shocked by this and thought that was wayyyy too much and was scared I would get iron overload, but he assured me that with my ferritin levels at a 9, it was desperately needed.

Within a week of supplementing with iron, I felt a big boost in energy and felt I had found the answer that I had been waiting for. While it did help, I reached a threshold of improvement that did not change despite continued supplementation with iron for over 1.5 years. The iron supplements did help with my heart palpitations, but I still had brain fog and fatigue. On a scale of 1-10, with 1 being my lowest point in the summer of 2020, iron brought me to about a 4.

My Third (Homecoming) Megadose

So time went on and I tried every supplement under the sun. I focused on vitamins and mitochondrial nutrients such as L-carnitine, alpha lipoic acid, CoQ10, and others, and I was able to live a life that looked kind of normal. But it didn’t feel normal. I was obsessed with finding the answer(s) to this dark cloud that had been engulfing me the past few years.

Until one day, just six months ago, in late April of 2023, a recommended video popped up on my YouTube homepage that changed my life. The video was from a smart lad named Elliot Overton talking about thiamine deficiency.

You probably know how the story goes.

I started with benfotiamine, because I could get it at the store, while I waited for my TTFD to arrive in the mail. I kept trying to press how much I could tolerate without too much headache/fatigue/brain fog, and I honestly can’t remember if I noticed an improvement in those first few days. Once my TTFD arrived though, within two days of supplementing I felt a rushing wave of beautiful relief come over me.

Finally. Finally! My answer had come. I wasn’t immediately better, but I knew improvement was on its way. It wasn’t long before I came across Hormones Matter, which brought me so much useful information! I began sleeping better. My dreams were more vivid. I was able to sweat more easily, something I didn’t know I had lost until it returned. The volume was turned down on my anxiety and breathing deeply was easier.

It took some adjusting and playing around with dosing to find out what would help me. At first, I could only consistently tolerate one 50 mg TTFD pill every-other day, or I would get a racing heart and worsened fatigue. I also noticed that after about a week of taking TTFD, I would start to feel drained, as if it wasn’t giving me that feeling of relief anymore. So what worked for me was to cycle TTFD, thiamine HCL, and sulbutiamine for one week each. That kept my feelings of “relief” heightened. I pretty much abandoned benfotiamine because, well, I had other stuff that was working and I didn’t want to change my routine.

Within about a month, I was able to take one TTFD per day. As time went on, I kept bumping up all of my doses for each type of thiamine. I would basically take a day to test how much I could handle, then try to sustain that higher new dose. By the end of July, I was taking 5-6 TTFD and 10-ish thiamine HCL (100mg each). I am not exactly sure with the doses. I believe I only made it up to 400 mg of sulbutiamine. At a certain point mid-summer, I dropped the sulbutiamine because it seemed to be making me feel depressed, even though it helped when I first began taking it. I also dropped the thiamine HCL. I felt that TTFD was more powerful and so I stuck with it. I no longer experienced a drop in “relief” symptoms and was able to take TTFD only without any adverse effects.

Somewhere between then and now I have worked myself up to 12-14 TTFD per day (600-700 mg). I have very little brain fog or fatigue and can work out without being drained the next several days. I feel pretty darn good most of the time. Of course, there are ebbs and flows, but overall, I am doing well.

In addition to the thiamine, I have been taking lots of support nutrients too, such as magnesium, multivitamin/B complex, selenium, molybdenum. Another major helper for energy has been 10-15 grams of creatine monohydrate per day. I eat a whole-foods diet with no added sugars.

My Fourth (Aha!) Megadose

Recently, I came across information by Linus Pauling, a Nobel Prize and Peace-Prize winner who championed high-dose vitamin C therapy for minor and major illnesses. I caught a cold around this same time, started high-dose vitamin C therapy, and was absolutely sold with the idea, as none of my symptoms really developed into much at all. While I’m not convinced of taking megadoses of vitamin C every single day, I am certain it is helpful during times of sickness.

Then I read about Orthomolecular Medicine, which uses high-dose vitamins for treating diseases (chronic, communicable, genetic), and it all made sense! I felt as though I had uncovered a secret to the world! I wouldn’t have believed it had I not experienced the “miracles” of megadosing first-hand, but now I realize that most, if not all, diseases can be treated with the right dose of specific nutrients for the right amount of time. I also realize that those doses are higher doses than what we think! And higher still! Yeah– even higher. And longer– yes, keep taking them. I don’t mean to oversimplify people’s illnesses, but rather to illustrate the power of high-dose vitamin therapy.

Then Versus Now

My healing journey is not quite over. I have tested positive for antinuclear antibodies since 2020, and my latest test (October 24, 2023) still tested positive (qualitative only). Finding out these results was a little disheartening, as I really thought my results would be negative. I have had less energy and some mild dysautonomic symptoms since receiving those results, which either means a) the power of suggestion has really gotten to me or b) I switched to thiamine HCL around the same time and it is not as effective as TTFD.  I am leaning towards the latter, but I wanted to give HCL more of a shot because the amount of TTFD I’m taking per day is getting expensive! And as a more recent update, the last two days I’ve tried Benfotiamine, which I have been very pleased with— my energy seems to be much better than with thiamine HCL.

I also just started alpha-GPC as a new supplement.

Here is some physical evidence that I am healing:

In one of my textbooks, I found that a B-vitamin deficiency (doesn’t say which B vitamin) causes a smooth tongue.

tongue vitamin B deficiency
Figure 1. Textbook images of vitamin B deficiency affecting the tongue.

I took a picture of my tongue in October 2020, and the second picture in October 2023. Notice the more prominent fuzzy (white/gray) projections in the second picture. These projections are quite blunted in the first picture.

Vitamin deficiencies and the tongue
Figure 2. Photographs of my tongue. Left: October 2020. Right: October 2023. The most prominent changes are on the sides and at the back of the tongue (more “fuzzy”). I believe these changes are in large part due to thiamine.

Hope for The Future

My husband and I are excited about the possibility of getting pregnant, especially now that I am feeling so much better. Having a child has been a long-time dream of mine, and while I was struggling with my health, I wasn’t sure if that dream could come to fruition. So now being in the place I’m in, I’m thrilled that we can think about having a child. I’ve had to tap the brakes on my excitement, because I don’t want to potentially cause any harm to a growing baby due to my megadosing of thiamine. So, I have a couple of questions.

Asking Advice:

  1. Does anyone have any research, personal, or hearsay information regarding the safety of megadose thiamine during pregnancy? If so, did the type matter (TTFD, thiamine HCL, Benfotiamine)?
  2. What is the maximum dose you reached for TTFD/thiamine HCL/Benfotiamine?
  3. Have any of you had any experience with weaning off of thiamine or stopping cold-turkey? I have gone a few days here and there without supplementing with no issue, but not longer than that. If so, was your health maintained, or was there a maintenance dose that sustained you?
  4. How did you know it was time to stop/decrease thiamine (if at all)?

Closing Thoughts

I just want to extend my heartfelt empathy for all of you who may be experiencing health struggles. Before these past few years, I sometimes had the arrogant thought that people could just be healthy if they avoided sugar and exercised. I thought their health struggles were their “fault”, to an extent, but I now recognize the complexity of health and the desperation in trying to find it once it is lost. I understand what suffering is and the feeling that there is no escape. I understand the feeling that no one truly knows what you are going through, even though they extend love and patience with you. I get it, and it sucks so much that this has to be a part of the human experience—but I have also experienced hope. A real hope. A hope that delivers what it promised. I could not have known even a day before taking thiamine that my time of deliverance had come. So please do not give up hope. Your day is coming.

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Photo by Tim Mossholder on Unsplash.


  1. Hi Torill,

    Did you ever figure out this issue? I came across a few studies in this website and from other sources about thiamine supplementation during pregnancy. The dosage of around 1.2mg per day seems to bring good results and has been tested thoroughly in pregnant woman, so I assume it’s safe. How they supplement it (which thiamine form) is not described in the research papers, so I’m wondering about that.

    • Hi Mauro,

      Thanks for asking!!! So after writing this post, I decided to try to wean myself off of TTFD very slowly (about 50 mg less per month, with a current dose of 500 mg). From about December to April, I made it down to 350 mg, but my body unfortunately couldn’t handle that and all of the fatigue and post-exertional malaise came back. So just the past few days I went back to 500 mg and I am feeling so much better.

      Yeah, unfortunately I don’t think there’s a ton of research in “megadosing” vitamin B1 during pregnancy. I believe just general thiamine HCL in large doses is likely safe in pregnancy. I’ve scoured the internet to find any information on TTFD and pregnancy specifically, because that’s the only form that seems to work for me (thiamine HCL and Benfotiamine only help very slightly for my fatigue— TTFD basically obliterates it).

      But, something that has given me some peace of mind is this random article from a hospital in Vietnam. They have a product that contains TTFD, vitamin B6, and vitamin B12, which has been approved during pregnancy. The product contains 50 mg of TTFD and the article says a pregnant woman can take up to 3 pills per day (=150 mg TTFD). They say not to take more than that, specifically to not get too much vitamin B6. But they say the TTFD has “very low toxicity and rare side effects.”

      In an ideal world, I wouldn’t have to take 500 mg of TTFD to feel normal (ideally, I wouldn’t have to take any!). But anyways, with all that I’ve read, it seems to be safe in pregnancy. Wish I had more broad research, but I will take what I can get.

      I think I have more healing to do (Tiffany’s comment has a good suggestion), but in the meantime, I am SO grateful that I have TTFD as a tool.

      Thanks for your comment and interest in my situation! I really appreciate it!


  2. Have you tried Limbic System Retraining as an addition to what you are already doing? Often when we go through chronic illness or traumatic events, it can keep us ‘stuck’ with symptoms that shouldn’t be there anymore once the ‘stressor’ has passed. I think it would be a really great thing to add to your regimen and may really help!

    • Hi Tiffany,

      Thanks for this suggestion! Don’t know why I’m just seeing your comment now! I have lightly researched and done some vagal nerve stimulation (to activate the parasympathetic nervous system), but I like the sound of Limbic System Retraining… I’ll definitely look into it. I really appreciate the suggestion!!!


    • I went based off of symptoms. As far as I know, there’s not a widely-used test that is very useful. Cheaper than a test is to just try it out B1 supplements! Not much of a risk (if any) with potential reward. Good luck!

  3. One thing that may work better than supplementation is taking a look at diet and lifestyle to understand where deficiencies come from. Avoid habits that deplete us, (coffee and smoking for example depletes vitamin C), and focus on foods high in the vitamins and minerals needed. We shouldn’t need convoluted supplement dosing habits for normal health, just a balanced healthy diet with some minor supplementation for minerals which are in shorter supply than they used to be, due to modern industrial farming practices.

    • Hi Bob,

      I agree that food and lifestyle ALWAYS must come first! Without those, there is no solid foundation. I eat whole foods (vegetables, fruit, meat, some organ meats, occasional grains), no processed foods, no seed oils, and no sugar. I haven’t had coffee or caffeine in a year, I’ve never smoked or drank.

      As Dr. Lonsdale describes in some of his posts on this website, taking thiamine isn’t necessarily as simple as repleting a deficiency. Thiamine modulates the activity of the mitochondria and when the mitochondria have been operating in a slowed-down state, they need mega-doses of thiamine to up-regulate their activity.

      People shouldn’t need convoluted supplement dosing habits for normal health— ideally. But when the body has been under huge amounts of stress (traumatic brain injury, antibiotics that inhibit thiamine absorption, etc.), these supplements can literally bring life back from a suffering state. Ideally, I do NOT want to be on all of these the rest of my life, but I am beyond grateful that I found them and they have brought me to a healthy state. If I need to be on them, so be it. There are no side effects.

      I also just passed a parasite yesterday, which was likely stealing some of my nutrients and was a burden on my system. I’m excited to see how I feel without it. But it’s remiss of you to claim that all we should need are healthy lifestyle and dietary habits to have full health. You wouldn’t have known that I had a parasite. I didn’t even know I had a parasite until a few days ago. But these and other factors can and do have an effect on our health, and even having the perfect diet and lifestyle habits wouldn’t have brought me to full health while having a parasite living inside of me.

      I agree that diet and lifestyle are absolutely cornerstones to health. You can’t be healthy without them. But many times, there are other factors that make being healthy more challenging for people. I am personally grateful for supplements, even if they seem “convoluted” to some.

  4. I discovered my thiamine deficiency in November 2015. I’ve been taking high dose TTFD and cofactor since then. Part of my story is on this website, so I won’t go into detail here again. However, I strongly suspect (and Dr. Lonsdale agreed based on my history) that I likely had it all my life. Even when I was pregnant. Of course, I was taking a prenatal supplement, but that had very little thiamine in it. I had gestational diabetes, which no one could explain. I was physically fit, worked out, and ate the supposed ideal diet. According to Dr. Lonsdale, 2 clues to my thiamine deficiency were found in my daughter at birth: a cataract and her jaundice. Since then (she was born 2006), I’ve come across research and literature about gestational diabetes and thiamine deficiency. I’ll try to post links here. I wish you good health and a healthy pregnancy.

    • Thanks so much for sharing your background and some research! Looking forward to reading through it. How much TTFD do you take daily? Have you ever tried to wean off of it?

  5. Doing a comprehensive stool analysis that includes a PCR test for commensal bacteria (microbiome) may shed some light onto why all of this happened in the first place. The GI infection you experienced wasn’t identified. Our gut bacteria play a significant role in our B vitamin absorption. They also produce some B vitamins for us.

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